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Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Our present study paves the way for exploring the blockade of EZH2 overexpression as a novel approach to treating cancer. Cancer Sci ; — Meanwhile, histone H3 Lys9 was methylated in all cell lines with silenced CDH1 , suggesting histone modification, including histone H3 Lys9, plays a pivotal role in transcriptional silencing of CDH1. However, at present, the underlying function of elevated EZH2 in cancer cells compared to normal cells is unknown.
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Enhanced radiosensitization of p 53 mutant cells by oleamide. Effect of oleamide, an endogenous fatty-acid primary amide, on tumor cells exposed to ionizing radiation IR has never before been explored. The cytotoxicity of oleamide alone or in combination with IR was determined by clonogenic survival assay, and induction of apoptosis was estimated by FACS analysis. Protein expressions were confirmed by Western blotting, and immunofluorescence analysis of Bax by use of confocal microscopy was also performed. The combined effect of IR and oleamide to suppress tumor growth was studied by use of xenografts in the thighs of nude mice.
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In cancer, mitochondrial functions are commonly altered. Directly involved in metabolic reprogramming, mitochondrial plasticity confers to cancer cells a high degree of adaptability to a wide range of stresses and to the harsh tumor microenvironment. Lack of nutrients or oxygen caused by altered perfusion, metabolic needs of proliferating cells, co-option of the microenvironment, control of the immune system, cell migration and metastasis, and evasion of exogenous stress e. Mitochondria are undoubtedly one of the key contributors to cancer development and progression. Understanding their protumoral dys functions may pave the way to therapeutic strategies capable of turning them into innocent entities.
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  • added: 22.07.2019
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