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E-mail address: damus cnuh. Email: damus cnuh. Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Turner syndrome TS , characterized by short stature and premature ovarian failure, is caused by chromosomal aberrations with total or partial loss of one of the two X chromosomes. Spontaneous puberty, menarche, and pregnancy occur in some patients depending on the abnormality of the X.
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GnRH-dependent precocious puberty manifested at the age of 14 months in a girl with 47,XXX karyotype

We aimed to investigate the association of DNAm profiling with the timing of human puberty analyzing the genome-wide DNAm patterns of peripheral blood leukocytes from ten female patients with central precocious puberty CPP and 33 healthy girls 15 pre- and 18 post-pubertal. For this purpose, we performed comparisons between the groups: pre- versus post-pubertal, CPP versus pre-pubertal, and CPP versus post-pubertal. Analyzing the methylome changes associated with normal puberty, we identified differentially methylated regions DMRs when comparing pre- and post-pubertal healthy girls. Only one genomic region, containing the promoter of ZFP57 , was hypomethylated in the pubertal group.
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Please take this quick survey to tell us about what happens after you publish a paper. This case report describes a 47,XXX girl who presented very early, at the age of 14 months, with signs of sexual precocity breast and pubic hair development, menarche and was finally diagnosed with GnRH dependent precocious puberty with no evidence of underlying central nervous system pathology. Though previous studies have shown a link between karyotype 47,XXX and precocious puberty, this is the youngest patient reported so far.
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